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03. Science and Technology (Natural Sciences) Committee

Permanent URI for this communityhttps://repository.unesco.gov.ph/handle/123456789/3

In creating a culture of peace and addressing sustainable development challenges, UNESCO aims to cultivate the generation and application of scientific knowledge among its Member States. At UNACOM, we facilitate access to UNESCO’s international programmes in the sciences, such as the Intergovernmental Oceanographic Commission (IOC), Man and the Biosphere (MAB) Programme, and International Geoscience and Geoparks Programme (IGGP), among others.

Through this sector, the Commission aims to contribute to the following SDGs: 11 - Sustainable Cities and Communities, 13 - Climate Action, 14 - Life Below Water, and 15 - Life On Land. With the overarching vision of the 2023-2028 Philippine Development Plan (PDP), UNACOM targets grassroots-inspired cultural heritage and biodiversity protection and conservation, as well as multi-stakeholder partnerships for SDGs promotion.

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Ocean Decade Challenge: search.filters.odc.Challenge 10: Change humanity’s relationship with the oceanUNESCO Keyword: search.filters.subject.Marine biology

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    Global mass spectrometric analysis reveals chemical diversity of secondary metabolites and 44-Methylgambierone production in Philippine Gambierdiscus strains
    Malto, Zabrina Bernice L.; Benico, Garry A.; Batucan, Jeremiah D.; Dela Cruz, James; Romero, Marc Lawrence J.; Azanza, Rhodora V.; Salvador-Reyes, Lilibeth A. (Frontiers Media SA, 2022-02-04)
    Surveillance and characterization of emerging marine toxins and toxigenic dinoflagellates are warranted to evaluate their associated health risks. Here, we report the occurrence of the ciguatera poisoning-causative dinoflagellate Gambierdiscus balechii in the Philippines. Toxin production and chemical diversity of secondary metabolites in G. balechii GtoxSAM092414, G. balechii Gtox112513, and the recently reported Gambierdiscus carpenteri Gam1BOL080513 were assessed using targeted and untargeted UPLC-MS/MS analysis and radioligand receptor-binding assay (RBA). 44-methylgambierone was produced by all three strains, albeitwith different levels based on RBA and UPLC-HRMS/MS analysis. The fatty acid composition was similar in all strains, while subtle differences in monosaccharide content were observed, related to the collection site rather than the species. Molecular networking using the GNPS database identified 45 clusters belonging to at least ten compound classes, with terpene glycosides, carbohydrate conjugates, polyketides, and macrolides as major convergence points. Species-specific peptides and polyhydroxylated compounds were identified in G. balechii GtoxSAM092414 and G. carpenteri Gam1BOL080513, respectively. These provide a glimpse of the uncharacterized biosynthetic potential of benthic dinoflagellates and highlight the intricate and prolific machinery for secondary metabolites production in these organisms.
    We would like to thank H. Junio and the Secondary Metabolites Profiling Laboratory of the Institute of Chemistry, University of the Philippines Diliman and K. B. Davis for assistance in the conduct of this study.