menu.header.image.unacom.logo
 

Journal Articles - UP - MSI

Permanent URI for this collectionhttps://repository.unesco.gov.ph/handle/123456789/50

Browse

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity
    Mangalindan, Gina; Talaue, Meliza; Cruz, Lourdes; Franzblau, Scott; Adams, Linda; Richardson, Adam; Ireland, Chris; Concepcion, Gisela (Georg Thieme Verlag KG, 2000-12-31)
    Marine sponge samples were collected in Baler, Aurora, Philippines, and extracts were tested for in vitro antituberculosis activity. An orange Agelas sp. sponge yielded the known compound, agelasine F, which inhibited some drug resistant strains of Mycobacterium tuberculosis in vitro at concentrations as low as 3.13 μg/ml. Activity against M. tuberculosis residing within macrophages required concentrations of 13 - 22 μg/ml which was below the IC50 for Vero cells (34 μg/ml).